炎痛喜康控释片在人体内的药动学研究
PHARMACOKINETIC STUDY OF CONTROLLED -RELEASE PIROXICAM TABLETS IN MAN
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摘要: 本文应用高效液相色谱法测定了8名健康受试者自身交叉服用炎痛喜康普通片与控释片(分别服用单剂量20mg)后的血药浓度。用非线性最小二乘模型嵌合的计算机程序对数据进行处理,表明该药在体内为一室模型,并求得各项参数如下:普通片,k_a=1.568h~(-1),k=0.0191h~(-1),V=7.9201,t_(max)=4.4h,C_(max)=2.502μg/ml,AUC=150.04h·μg/ml;控释片,ka=0.185h~(-1),k=0.0223h~(-1),V=7.3561,t_(max)=15.3h,C_(max)=2.048μg/ml,AUC=129.63h·μg/ml.
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