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静注Michaelis—Menten消除动力学稳态浓度的理论研究[J]. 中国药科大学学报, 1990, (4): 232-233.
引用本文: 静注Michaelis—Menten消除动力学稳态浓度的理论研究[J]. 中国药科大学学报, 1990, (4): 232-233.
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Drug Plasma Concentration at Steady-State by Bolos Intravenous Administration in Michaelis-Menten Elimination Kinetics[J]. Journal of China Pharmaceutical University, 1990, (4): 232-233.
Citation: Drug Plasma Concentration at Steady-State by Bolos Intravenous Administration in Michaelis-Menten Elimination Kinetics[J]. Journal of China Pharmaceutical University, 1990, (4): 232-233.
shu

静注Michaelis—Menten消除动力学稳态浓度的理论研究

Drug Plasma Concentration at Steady-State by Bolos Intravenous Administration in Michaelis-Menten Elimination Kinetics

    摘要
  • 摘要: Michaelis—Menten消除动力学(下称米氏型消除)是非线性药物动力学中的重要部分。大量临床研究表明,呈药动学非线性特征的药物,尤有必要进行血药浓度监测。本

     

    Abstract: For intravenous injection in Michaelis-Menten elimination kinetics, the equations of maximal plasma, minimal plasma concentration and average one at steady-state were derived. It is shown that the Wagner' equation for average plasma concentration at stead

     

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