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噻吩骈嘧啶二酮衍生物的合成及其抑酶活性[J]. 中国药科大学学报, 1991, (3): 142-144.
引用本文: 噻吩骈嘧啶二酮衍生物的合成及其抑酶活性[J]. 中国药科大学学报, 1991, (3): 142-144.
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Synthesis and Inhibitor Activity to Phosphodiesterase of Thieno [3, 4-d] Pyrimidine-2,4-Dione Derivatives[J]. Journal of China Pharmaceutical University, 1991, (3): 142-144.
Citation: Synthesis and Inhibitor Activity to Phosphodiesterase of Thieno [3, 4-d] Pyrimidine-2,4-Dione Derivatives[J]. Journal of China Pharmaceutical University, 1991, (3): 142-144.
shu

噻吩骈嘧啶二酮衍生物的合成及其抑酶活性

Synthesis and Inhibitor Activity to Phosphodiesterase of Thieno 3, 4-d Pyrimidine-2,4-Dione Derivatives

    摘要
  • 摘要: 为了寻找新的磷酸二酯酶(PDE)抑制剂,以茶碱为先导化合物,氰乙酸和氨基甲酸乙酯为原料,经中间体N-取代-5-氰基脲嘧啶,合成了12个噻吩骈3,4-d嘧啶-2,4-二酮类化合物。它们对PDE有不同程度的抑制活性,其中3-甲基-1-邻甲基苯基-5-氨基噻吩骈3,4-d嘧啶-2,4-二酮活性较强。

     

    Abstract: In search of novel phosphodiesterase (PDE) inhibitors, twelve compounds of thieno 3,4-d pyrimidiine-2,4-diones (V a-1) were designed and synthesized with cyanoacetic aicd and urethan taken as the starting materials. Condensation and cyclization were inv

     

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