阿司匹林肠溶片水性包衣技术的研究

Studies on Aqueous Coating Technique for Acetylsalicylic Acid Enteric Tablets

摘要: 从崩解时限、泄漏率及药物稳定性等方面对阿司匹林的有机溶媒包衣和水性包衣进行了比较,实验表明,两种包衣系统均能产生良好的肠溶特性;扫描电镜结果显示,在水性胶乳系统的成膜过程中,单个聚合物粒子已完全融合成均匀、连续的膜,其外观的光滑程度超过了有机溶媒系统。

Abstract: A comparative evaluation was conducted between organic solvent coating and aqueous coating systems for acetylsalicylic acid tablets in disintegration time, diffusion of active material and drug stability. Result showed that both the systems could present