稳态乙胺碘呋酮对乙酰普鲁卡因胺的药物动力学和QT间期延长作用的影响

Effect of Steady State Amiodarone on the Pharmacokinetics and QT Interval. Prolongation of N-Acetylprocainamide

摘要: 采用药动学-药效学结合模型研究稳态乙胺碘呋酮对乙酰普鲁卡因胺(NAPA)的药动学和QT间期延长作用的影响,兔单独ⅳNAPA后,其β,K_(eo),S,EC_(50),E_(max)分别为0.0060±0.0006 min~(-1),0.061±0.017 min~(-1),2.19±0.39,6.21±1.74 μg/ml,53.6±2.5 ms;在稳态乙胺碘呋酮存在下ⅳNAPA后,分别为0.0086±0.0007 min~(-1),0.024±0.006 min~(-1),1.56±0.15,2.48±0.12 μg/ml,88.3±7.1 ms,结果表明乙胺碘呋酮可以增强并延长NAPA对QT间期的延长作用,并使NAPA的药物动力学和效应动力学的某些参数发生变化。