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许激扬, 吴梧桐, 金生浩, 姚文兵. 化学－酶法合成甜味天苯二肽[J]. 中国药科大学学报, 1994, (1).
引用本文: 许激扬, 吴梧桐, 金生浩, 姚文兵. 化学－酶法合成甜味天苯二肽[J]. 中国药科大学学报, 1994, (1).
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Xu Jiyang, Wu Wutong, Jin Shenghao, Yao Wenbin. Chemico-Enzymatic Synthesis of Sweetener Aspartame[J]. Journal of China Pharmaceutical University, 1994, (1).
Citation: Xu Jiyang, Wu Wutong, Jin Shenghao, Yao Wenbin. Chemico-Enzymatic Synthesis of Sweetener Aspartame[J]. Journal of China Pharmaceutical University, 1994, (1).
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化学－酶法合成甜味天苯二肽

Chemico-Enzymatic Synthesis of Sweetener Aspartame

    摘要
  • 摘要: 为探索天－苯甜二肽生产新技术，以马来酐与Ｌ－苯丙氨酸甲酯为原料经化学法缩合成马来酰－Ｌ－丙氨酸甲酯，并将后者异构化成富马酰－Ｌ－苯丙氨酸甲酯（ＦＰＭ），收率９５％；再以ＦＰＭ及氨或氨供体为底物，经Ｅ．ｃｏｌｉＣＰＵ８９０１转化为天－苯甜二肽，产物浓度为５．６ｍｇ／ｍｌ。

     

    Abstract: This paper deals with the chemico-enzymatic synthesis of sweetener aspartame. N-Maleylphenylalanine methyl ester was prepared by treating maleic anhydrid with L-phenylalanine methyl ester and isomerized to N-fumarylphenylalanine methyl ester (FPM),yield 9

     

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