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米索前列醇固态分散体的制备及其稳定性研究[J]. 中国药科大学学报, 1994, (3): 145-148.
引用本文: 米索前列醇固态分散体的制备及其稳定性研究[J]. 中国药科大学学报, 1994, (3): 145-148.
shu
Stability of Solid Dispersions of Misprostol[J]. Journal of China Pharmaceutical University, 1994, (3): 145-148.
Citation: Stability of Solid Dispersions of Misprostol[J]. Journal of China Pharmaceutical University, 1994, (3): 145-148.
shu

米索前列醇固态分散体的制备及其稳定性研究

Stability of Solid Dispersions of Misprostol

    摘要
  • 摘要: 采用溶剂法制备了米索前列醇－ＰＶＰ－ＥＣ固态分散体，经差示扫描量热法，扫描电子显微镜技术，红外光谱分析及稳定性实验表明：米索前列醇固态分散体的化学稳定性较原料药本身有显著提高，选用不同溶剂，米索前列醇与ＰＶＰ的不同比例及不同分子量的ＰＶＰ制备固态分散体对米索前列醇的化学稳定性无影响，经加速实验表明本品有较好的抗湿作用，溶解度实验表明本品的溶解度较原料有显著提高。

     

    Abstract: The misoprostol-PVP-EC solid dispersions were prepared by a solvent method.The chemical stability and water solubility of misoprostol-PVP-EC solid dispersions were studied.It was found that misoprostol in its PVP and C dispersions was chemically stable to

     

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