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洛美沙星滴耳液的高效液相色谱分析[J]. 中国药科大学学报, 1994, (4): 42-45.
引用本文: 洛美沙星滴耳液的高效液相色谱分析[J]. 中国药科大学学报, 1994, (4): 42-45.
shu
Study on the Determination of Lomefloxacin Otic Solution by High-Performance Liquid Chromatography[J]. Journal of China Pharmaceutical University, 1994, (4): 42-45.
Citation: Study on the Determination of Lomefloxacin Otic Solution by High-Performance Liquid Chromatography[J]. Journal of China Pharmaceutical University, 1994, (4): 42-45.
shu

洛美沙星滴耳液的高效液相色谱分析

Study on the Determination of Lomefloxacin Otic Solution by High-Performance Liquid Chromatography

    摘要
  • 摘要: 采用反相HPLC法测定滴耳液中洛美沙星及其杂质的含量。采用TSk gel~(TM)C_(18)色谱柱,乙腈-0.1％三乙胺溶液(16:84,以磷酸调节pH为2.5)作流动相,检测器波长287nm。含量测定采用内标法,以诺氟沙星为内标,杂质检查采用面积归一化法。实验结果表明,该方法对杂质的分离度好,含量测定的平均回收率为99.85％(RSD=0.41％,n=5)。

     

    Abstract: This paper deals with a method for determination of lomefloxacin and its impurities in lomefloxacin otic solution by RP-HPLC using ODS column and a UV detector at 287 nm. The mobile phase is a mixture of acetonitrile and 0. 1 % triethylamine (16 : 84, adj

     

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