老化对磷酸烯醇型丙酮酸激酶基因转录作用的影响
Effect of Age on the Gene Transcription of Phosphoenolpyruvate Carboxykinase
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摘要: 使用６￣２６月龄Ｆｉｃｈｅｒ３４４禁食雄性大鼠肝脏研究了老化对磷酸烯醇型丙酮酸激酶（ＧＴＰ）（ＰＥＰＣＫ．ＥＣ．４．１．１．３２）基因表达的影响，结果表明６￣２６月龄大鼠肝脏提取物中的ＰＥＰＣＫ活力约下降５０％，且与年龄相关的ＰＥＰＣＫ活性的下降与ＰＥＰＣＫ ｍＲＮＡ水平的下降相平行。因此，ＰＥＰＣＫ活性的下降可能是因用于进行转译作用的ｍＲＮＡ的转录作用下降，且６月龄到２６月龄大鼠肝脏的ＰＥＰＣＫAbstract: The effect of age on the gene expression of phosphoenolpyruvate carboxykinase(GTP)(PEPCK,EC 4.1.1.32) was studied by using hepatocytes isolated from 6 to 26 month old male Fischer 344 rats fasted for 12 h.The activity of PEPCK in hepatocyte extracts decre
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