复方美沙芬片的HPLC分析

Determination of Dextromethorphan Hydrobromide,Pseudoephedrine Hydrochloride and Chlorpheniramine Meleate in Compound Dextromethorphan Tablets by HPLC

摘要: 对新药复方美沙芬片中美沙芬、盐酸伪麻黄碱和扑尔敏的ＨＰＬＣ分析进行了研究，考察了流动相组成、ｐＨ等对分离的影响情况。以盐酸萘甲唑啉为内标，检测波长为２６５ｎｍ，在所测范围内，峰面积与被测物浓度的线性关系良好。美沙芬、盐酸伪麻黄碱和扑尔敏平均回收率分别为９８．９２％，９８．７３％和９８．４５％，ＲＳＤ〈１．０２％（ｎ＝５）。
- 美沙芬 /
- 复方美沙芬片 /
- 盐酸伪麻黄碱 /
- 扑尔敏 /
- HPLC
Abstract: A sensitive and simplified high performance liquid chromatographic procedure was develoed to determine dextromethorphan hydrobromide,pseudoephedrine hydrochloride and chlorpheniramine meleate in Compound Dextromethorphan Tablets.Naphazoline hydrochloride
- Dextromethorphan hydrobromide /
- Compound Dextromethorphan Tablet /
- Pseudoephedrine hydrochloride /
- Chlorpheniramine meleate /
- HPLC