氟喹诺酮类抗菌剂氟罗沙星合成工艺研究

氟喹诺酮类抗菌剂氟罗沙星合成工艺研究[J]. 中国药科大学学报, 1995, (6): 321-323.

引用本文:

氟喹诺酮类抗菌剂氟罗沙星合成工艺研究[J]. 中国药科大学学报, 1995, (6): 321-323.

Studies on Synthesis of Fluoroquinolone Antimicrobial Agent Fleroxacin[J]. Journal of China Pharmaceutical University, 1995, (6): 321-323.

Citation:

Studies on Synthesis of Fluoroquinolone Antimicrobial Agent Fleroxacin[J]. Journal of China Pharmaceutical University, 1995, (6): 321-323.

Studies on Synthesis of Fluoroquinolone Antimicrobial Agent Fleroxacin

摘要: 氟罗沙星由２，３，４－三氟硝基苯经还原、缩合环合、氟乙基化、螯合、上甲基哌嗪、水解、精制等七步反应制得。反应条件温和，副反应少，总收率达４０％。

Abstract: An improved synthesis of antibacterial agent fleroxacin,starting from 2,3,4-trifluoronitrobenzene via reduction,condensation-cyclization,fluoroethylation,chelation,piperazination,hydrolysis,etc,was described.The reactions of all steps were carried out und

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