酮基布洛芬涂膜剂的制备及控释机理研究
Studies on the Ketoprofen Transdermal Therapeutic System
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摘要: 研制了酮基布洛芬经皮吸收涂膜剂;通过体外渗透试验,探讨了涂膜剂的控释机理。结果表明,涂膜剂中酮基布洛芬以零级动力学经皮吸收,渗透速率与聚合物限速膜厚度的倒数呈良好线性关系(r=0.992)。Abstract: A ketoprofen film was developed and its controlled release mechanism was studied.The permeation of ketoprofen in the film through the rats skin followed zero-order kinetics and the permeation rate was proportional to the reciprocal of the membrane thickne
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Keywords:
- Ketoprofen /
- Film /
- Permeation rate /
- Controlled relcase
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