格列吡嗪缓释片的制备及其释药特性的研究

Studies on the Preparation and Release Characteristic of Glipizide Hydrophilic Gel Tablets

摘要: 研究了羟丙甲纤维素（ＨＰＭＣ）水凝胶型格列吡嗪缓释片的制备及其释药特性。结果表明，药物从ＨＰＭＣ水凝胶骨架片中的释放符合零级动力学过程，其零级释药速率受到多种因素，如ＨＰＭＣ的型号、规格、用量，附加剂，制剂的大小与形状及压力的调节和控制。

Abstract: Glipizide hydrophilic gel tablets containing hydroxypropylmethyl-cellulos(HPMC) were prepared, and their drug release characteristic was also evaluated.The results indicated that the drug release process could be best described by zero-order kinetics mech