低分子量肝素对血凝及动,静脉血栓形成的影响
Effect of Low Molecular Weight Heparin on Coagulation System and Thrombosis
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摘要: 以标准肝素(SH)为原料经亚硝酸裂解制备的低分子量肝素(LMWH),给予同等抗Xa单位剂量时,对凝血系统的影响较SH小,在治疗量下(100anti-XaIU/kg)不增加出血倾向;体外实验表明,LMWH能有效地抑制chandler模型的血栓形成;体内实验表明,LMWH在100~200antiXaIU/kg范围内能有效地抑制大鼠动-静脉旁路、大鼠颈动脉电流损伤(iv,sc)和家兔颈静脉血栓模型的血栓形成,与参照品Fragmin及SH的作用相似,LMWH在上述模型中的ED50分别为:159,185(iv),193(sc),91anti-XaIU/kg;研究还发现,scLMWH吸收完全,给药后3h的抗血栓作用与iv后10min相似,而SH的作用弱。提示LMWH保留了SH的抗血栓作用,降低了SH的出血副作用。Abstract: Low molecular weight haprin(LMWH) was obtained by controlled nitrous acid degradation of standard heparin(SH).It was demonstrated that 1) LMWH has less effect on coagulation system than SH;2) The anti-thrombotic potency of LMWH was weaker,compared to that