头孢泊肟酯合成研究Ⅰ．1－碘乙基异丙基碳酸酯的制备

Research Institute of Applied Pharmacy,China Pharmaceutical University,Nanjing 210009

摘要: 报道β－内酰胺类抗生素－头孢泊肟酯４位侧链中间体１－碘乙基异丙基碳酸酯的合成步骤，应用参数设计技术对１－氯乙基氯甲酸酯和１－氯乙基异丙基碳酸酯制备的工艺参数进行优化，收率分别达到５８．６％和７０％，均超过文献值，且简化了工艺，缩短了反应时间，易于工业化生产。
- 头孢泊肟酯 /
- 1-碘乙基异丙基碳酸酯 /
- 1-氯乙基氯甲酸酯 /
- 1-氯乙基异丙基碳酸酯 /
- 参数设计 /
- 因子分析
Abstract: The synthesis steps of 1 iodoethyl isopropyl carbonate were reported. 1 Iodoethyl isopropyl carbonat is an intermedicate at the 4th position side chain of cefpodoxime Proxetil one of antibiotics of B lactams. A parameter design method was applied to s
- cefpodoxime proxetil /
- 1 iodoethyl isopropyl carbonate /
- 1 iodoethyl chloroformate /
- 1 iodoethyl isopropyl carbonate /
- parameter design /
- factorial analysis