Abstract: A new synthetic method of a new tricyclic fluoroquinolone rufloxacin hydrochloride(1) is designed. This method has not been reported in literature in 32.5% yield. Rufloxacin hydrochloride has been prepared in eight steps from 2, 3, 4-trifluo ronitrobenzene through substitution,reduction,bromization,cyclization,condensatio n-cyclizatio n, chelation,N-methylpiperazina tion,and hydrolysis.