抗心律失常药盐酸索他洛尔的合成

抗心律失常药盐酸索他洛尔的合成[J]. 中国药科大学学报, 1997, (3): 4-6.

引用本文:

抗心律失常药盐酸索他洛尔的合成[J]. 中国药科大学学报, 1997, (3): 4-6.

Synthesis of Anti-arrhythymic Sotalol[J]. Journal of China Pharmaceutical University, 1997, (3): 4-6.

Citation:

Synthesis of Anti-arrhythymic Sotalol[J]. Journal of China Pharmaceutical University, 1997, (3): 4-6.

Synthesis of Anti-arrhythymic Sotalol

摘要: 以苯胺为原料,经甲磺酰氯的酰化反应,溴乙酰溴的傅克酰化反应和异丙胺的分子间亲核取代反应及还原四步合成盐酸索他洛尔。经工艺改进,各步收率均有较大的提高,总收率达44.83％。

Abstract: Starting from aniline, and undergoing mesylation, Friedel-Crafts acylation, isopropylami-nation and hydrogenation, sotalol hydrochloride was synthesized. The yields of every step were promoted by modifying the reacting conditions. The total yield reaches

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