两种高脂饲料致鹌鹑动脉粥样硬化病变的比较
Comparasion of Atherosclerosis Formation Induced by Two Kinds of Rich-fat Diets in Quails
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摘要: 持续用高脂Ⅰ、高脂Ⅱ饲料喂养鹌鹑7周后,血清TC、TG、LDL-C、VLDL-C和AI明显升高,HDL-C、HDL_2-C、HDL_3-C及HDL-C/TC和HDL_2-C/HDL_3-C值明显降低。动脉壁TG、TC、CE、MDA含量及CE/TC值均明显升高,而且,主动脉内膜形成了明显的动脉粥样硬化斑块,病理检查表明:高脂Ⅱ组较高脂Ⅰ组的病变程度更高。吉非罗齐(50,100mg/kg)能明显改善高脂饲料引起的鹌鹑血脂紊乱,减少胆固醇及其酯在动脉壁的沉积,抑制动脉粥样硬化。Abstract: 60 male Korean quails were divided into 5 groups at random. Group I: on stock diet; Group II:on rich-fat diet I; Group III: on rich-fat diet II ; Group IV: on, rich-fat diet II Gem-fibrozil (50 mg/kg/d, po) ; Group V: on rich-fat diet II Gemfibrozil (
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