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HPLC Analysis of Metoprolol and Its Metabolites in the Perfusates[J]. 中国药科大学学报, 1997, (6): 31-35.
引用本文: HPLC Analysis of Metoprolol and Its Metabolites in the Perfusates[J]. 中国药科大学学报, 1997, (6): 31-35.
HPLC Analysis of Metoprolol and Its Metabolites in the Perfusates[J]. Journal of China Pharmaceutical University, 1997, (6): 31-35.
Citation: HPLC Analysis of Metoprolol and Its Metabolites in the Perfusates[J]. Journal of China Pharmaceutical University, 1997, (6): 31-35.

HPLC Analysis of Metoprolol and Its Metabolites in the Perfusates

HPLC Analysis of Metoprolol and Its Metabolites in the Perfusates

  • 摘要: 利用C18柱和由水-乙腈-三乙胺(91:9:0.3,V/V/V)组成并用磷酸调节pH至3的流动相,在激发波长为224nm和不加发射滤光片条件下,以nadolol为内标,建立了测定美多心安及其代谢物的高效液相色谱法,验证了其准确性和精密度,并例证该法可应用于测定肝脏灌流实验中灌流液美多心安及其代谢物的浓度。

     

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