LC／MS分析克拉霉素降解产物

LC/MS Analysis of Degradation Products of Clarithromycin

摘要: 采用高效液相色谱／电喷雾离子化质谱法分离并测定了克拉霉素在酸、碱、光照以及氧化条件下的降解产物。结果表明：克拉霉素在酸性条件下主要分解途径为水解去一分子克拉啶糖；在碱性条件下分解产物有：克拉霉素的同分异构体、脱水产物以及内酯开环和分解产物；在氧化条件下形成过氧化物；在光照条件下则较为稳定。分解产物结构分析未见文献报道

Abstract: Online HPLC/ESI/MS was used to identify the degradation products of clarithromycin The acidic decomposition product is 5 O desosaminyl 6 O methylerythronolide Under basic condition, the degraded products are dehydration product, ring ope