5—单硝酸异山梨醇酯对冠脉结扎大鼠心肌梗塞的保护作用
The Therapeutical Effect of Isosorbide-5-Mononitrate on Myocardial Infraction in Coronary Artry Ligated Rats
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摘要: 用冠脉结扎模型观察5－单硝酸异山梨醇酯（Isosorbide－5－mononitrate，IS－5－MN）对大鼠心肌梗塞的保护作用，并与双硝基异山梨醇酯（Isosorbiddinitrate，ISDN）进行比较。静脉给药后，IS－5－MN可明显减少心肌梗塞范围，显著降低血清中乳酸脱氢酶（LDH）和磷酸肌酸激酶（CK）活性，减少J点的位移，对心率（HR）无显著影响。IS－DN的作用与等剂量的IS－5－MN的作用相似。结果提示：IS－5－MN与ISDN一样，对冠脉结扎引起的大鼠心肌梗塞有一定保护作用。Abstract: The effects of lsosor bide - 5 - mononitrate (IS- 5 - MN ) and isosorbide dinitrate (ISDN ) on myocardial infraction in coronary artery ligated rats were studied. It was shown that IS-5-MN decreased myocardial infraction size,LDH and CK in serum and the s
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