降糖药格列美脲的合成工艺研究

降糖药格列美脲的合成工艺研究[J]. 中国药科大学学报, 1999, (3): 3-5.

引用本文:

降糖药格列美脲的合成工艺研究[J]. 中国药科大学学报, 1999, (3): 3-5.

Studies on Synthesis of Antidiabetic Glimepiride[J]. Journal of China Pharmaceutical University, 1999, (3): 3-5.

Citation:

Studies on Synthesis of Antidiabetic Glimepiride[J]. Journal of China Pharmaceutical University, 1999, (3): 3-5.

Studies on Synthesis of Antidiabetic Glimepiride

摘要: 以乙酰乙酸乙酯为起始原料,经八步反应制得新降糖药格列美脲(glimepiride) ,总收率为11 .5 % ,反应原料易得,反应条件温和,后处理方便,适合工业化生产。

Abstract: Antidiabetic glimepiride is pharmacologically distinct from other sulfonylureas with a profile of potent and long lasting blood glucose lowering effect. Glimepiride was synthesized via eight steps with ethyl acetoacetate as starting material. The total y

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