止吐药昂丹司琼的合成

Synthesis of Ondansetron Hydrochloride

摘要: 以１，３环己二酮为起始原料，形成单苯腙后，经过环合、甲基化得９甲基１，２，３，９四氢４Ｈ咔唑４酮（３），与吗啉及多聚甲醛进行Ｍａｎｎｉｃｈ反应，再与２甲基咪唑反应、成盐得标题化合物，总收率为４９１％。

Abstract: An improved process for the preparation of ondansetron hydrochloride (1) is described . Compound 1 wassynthesized from 1 ,2 ,3 ,9 tetrahydro 9 methyl 4 H carbazol 4 one(3) by Mannich reaction and condensation with 2 methylimidazole . The compou