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高效液相色谱法测定人血浆中异烟肼和吡嗪酰胺的含量[J]. 中国药科大学学报, 2000, (2): 27-29.
引用本文: 高效液相色谱法测定人血浆中异烟肼和吡嗪酰胺的含量[J]. 中国药科大学学报, 2000, (2): 27-29.
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Determination of Isoniazid and Pyrazinamide in Plasma by HPLC[J]. Journal of China Pharmaceutical University, 2000, (2): 27-29.
Citation: Determination of Isoniazid and Pyrazinamide in Plasma by HPLC[J]. Journal of China Pharmaceutical University, 2000, (2): 27-29.
shu

高效液相色谱法测定人血浆中异烟肼和吡嗪酰胺的含量

Determination of Isoniazid and Pyrazinamide in Plasma by HPLC

    摘要
  • 摘要: 建立了同时测定人血浆中异烟肼和吡嗪酰胺的反相高效液相色谱法。色谱柱Ｌｉｃｈｒｏｓｐｈｅｒ １００ＲＰ－Ｃ８（５μｍ）流动相为乙腈（Ａ）：０．０５ｍｏｌ／Ｌ磷酸二氢钾（Ｂ）（每５００ｍｌ中加入三乙胺约２００μｍｌ调ｐＨ５．６），检测波长２７０ｎｍ。线性范围分别为０．１￣１０μｇ／ｍｌ和１￣４０μｇ／ｍｌ，方法回收率分别为大于９０％和８２％，日内，日间差皆小于１０％。

     

    Abstract: A HPLC method was established to determine the plasma concentration of isoniazid and pyrazinamide. Lichrospher 100 RP C 8 was used as a statephase. A linear gradient delution was used from a binary system consisting of solvent A (acetonitrile ) and solv

     

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