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铂类抗癌药物体内药物浓度的电热原子吸收光谱分析[J]. 中国药科大学学报, 2000, (3): 55-59.
引用本文: 铂类抗癌药物体内药物浓度的电热原子吸收光谱分析[J]. 中国药科大学学报, 2000, (3): 55-59.
The Determination of Concentration in Body of Platinum-based Anti-Cancer Drugs by Electrothermal Atomic Absorption Spectroscopy[J]. Journal of China Pharmaceutical University, 2000, (3): 55-59.
Citation: The Determination of Concentration in Body of Platinum-based Anti-Cancer Drugs by Electrothermal Atomic Absorption Spectroscopy[J]. Journal of China Pharmaceutical University, 2000, (3): 55-59.

铂类抗癌药物体内药物浓度的电热原子吸收光谱分析

The Determination of Concentration in Body of Platinum-based Anti-Cancer Drugs by Electrothermal Atomic Absorption Spectroscopy

  • 摘要: 应用电热原子吸收光谱分析技术(EAAS)对血浆、尿液、胆汁及各种组织中的总铂的含量进行了测定。研究表明,经合理的原子化程序设定后,尿液和胆汁可以不加处理直接进样,血浆用0.25%,TritonX-100等量稀释,组织只采用简单快捷的均相酸消化法。本方法精密度RSD〈10%,回收率87.40%~110.0%,在0.08~5.00μg/ml铂浓度范围一关系良好,相关系数r〉0.9962适合于铂类药物药

     

    Abstract: The improved methods for the determination of total platinum in a large number of different tissuses and body fluids by electrothermal atomic absorption spectroscopy were described.Urine and bile were analyzed without pretreatment. Plasma was analyzed aft

     

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