淫羊藿总黄酮对维A酸诱导大鼠骨质疏松症的防治作用

Effect of HEF onOsteoporosis Induced by Retinoic Acid in Male Rats

摘要: 以９０ｍｇ／ｋｇ维Ａ酸结合低钙饲料诱导大鼠有质疏松症，模型组在鼠血清碱性碳酸酶（ｓ－ＡＬＰ）生碱性磷酸酶（ＨＩＳ－ｓ－ＡＬＰ）显著升高，股骨、胫骨骨重（Ｗ）下降，骨表观线密度（Ｗ／Ｌ）、表观面密度（Ｗ／ＬＤ）、骨灰重（Ｗａｓｈ）、灰分表观线密度（Ｗａｓｈ／Ｌ）及灰分表观面密度（Ｗａｓｈ／ＬＤ）明显降低。淫羊萑总黄酮７５、１５０、３００ｍｇ／ｋｇ连续给药一个月，可降低模型大鼠的Ｓ－ＡＬＰ与ＨＩＳ－Ｓ

Abstract: Rat osteoporosis models induced by Retinoic Acid(RA)cooperated with low calcium fodder were used to evaluate the function of HEF. Three doses of HEF(75,150 and 300 mg/kg)were given for one month by oral administration. Compared with model group, HEF could