2—（1H）—喹啉酮类化合物的合成及降压活性

Synthesis and Bio-activity Study of the 2(1H)-Quinolone Compounds

摘要: 设计并合成了１０个含２（１Ｈ）－喹啉酮结构的ＤＤＰＨ类似物，其结构均经红上光谱、氢核磁共振谱、元素分析、质谱或高分辩质谱确证。改进了关键中间体４－省甲基－２（１Ｈ）－喹啉酮的制备。所有的化合物均进行了动物急性降压试验，一些化合物显示出良好的降压活性。

Abstract: Ten analogs of DDPH, which contain 2(1H) quinolone moiety, were synthesized and their structures were confirmed by IR, elemental analysis, \ 1H NMR and mass spectrum. The reported procedure for synthesis of key intermediate 4 bromomethyl 2(1H) quinol