来氟米特的合成研究

来氟米特的合成研究[J]. 中国药科大学学报, 2000, (5): 10-11.

引用本文:

来氟米特的合成研究[J]. 中国药科大学学报, 2000, (5): 10-11.

Studies on Synthesis of Leflunomide[J]. Journal of China Pharmaceutical University, 2000, (5): 10-11.

Citation:

Studies on Synthesis of Leflunomide[J]. Journal of China Pharmaceutical University, 2000, (5): 10-11.

Studies on Synthesis of Leflunomide

摘要: 以乙酰乙酸乙酯为起始原料，经五步反应制得来氟米特，总收率为４３．６％，反应原料易得，反应条件温和，后处理方便，适合工业化生产。

Abstract: Leflunomide was synthesized via five steps with ethyl acetoacetate as starting material. The total yield was 46.3%. The condition of reaction was mild and suitable for industry-scale manufacture.

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