栀子西红花总甙对神经、心血管及呼吸系统的影响

Effects of Crocins Extracted from Gardenia jasminoides Ellis on Nervous, Cardiovascular and Respiratory Systems

摘要: 栀子西红花总甙（７．５，１５及３０ｍｇ／ｋｇ，ｉｖ）对麻醉犬颈动脉收缩压（ＳＡＰ），舒张压（ＤＡＰ），平均压（ＭＡＰ），心率（ＨＲ），心电图各参数（Ｐ－Ｒ间期、ＱＲＳ波、Ｑ－Ｔ间期、Ｔ波），呼吸频率及呼吸幅度无明显影响；栀子西红花总甙（３５ｍｇ／ｋｇ，ｉｖ）对小鼠自发活动和机能协调功能无明显影响，与阈下戊巴比妥钠也无明显协同作用；栀子西红花总甙（７０ｍｇ／ｋｇ，ｉｖ）可明显减少小鼠自发活动，但对小鼠机能协调功能无显著影响，与阈下戊巴比妥钠也无明显协同作用；栀子西红花总甙（１４０ｍｇ／ｋｇ）不仅明显减少小鼠自发活动，而且显著影响小鼠机能协调功能，与阈下戊巴比妥钠有明显协同作用。

Abstract: Crocins (7.5, 15, 30 mg/kg, iv) had no pronounced influences on systolic pressure, diastolic pressure, mean arterial pressure, heart rate, and t he parameters of ECG in anaesthetized dogs, and had no evident effects on the f requency and amplit ude of re