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脂质体阿霉素与游离阿霉素在大鼠体内药代动力学[J]. 中国药科大学学报, 2001, (5): 36-40.
引用本文: 脂质体阿霉素与游离阿霉素在大鼠体内药代动力学[J]. 中国药科大学学报, 2001, (5): 36-40.
Study on Pharmacokinetics and Tissue Distribution of Free Doxorubicin andLiposomal Doxorubicin in Rats[J]. Journal of China Pharmaceutical University, 2001, (5): 36-40.
Citation: Study on Pharmacokinetics and Tissue Distribution of Free Doxorubicin andLiposomal Doxorubicin in Rats[J]. Journal of China Pharmaceutical University, 2001, (5): 36-40.

脂质体阿霉素与游离阿霉素在大鼠体内药代动力学

Study on Pharmacokinetics and Tissue Distribution of Free Doxorubicin andLiposomal Doxorubicin in Rats

  • 摘要: 目的测定大鼠血清及组织中阿霉素的血药浓度,研究大鼠静脉给药后脂质体阿霉素(L-DOX)与游离阿霉素(F-DOX)药代动力学规律及组织分布特征(靶向定位特征).方法采用RP-HPLC法测定阿霉素浓度.色谱柱Nova-Pak

     

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