LC—MS法测定健康受试者口服盐酸班布特罗后血浆中特布它林的浓度

Quantitative Determination of Terbutaline in Human Plasm After Administration of Bambuterol Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry

摘要: 目的：研究健康受试者口服盐酸班布特罗后血浆中特布它林浓度LC－MX测定方法。方法：血浆中特布它林溶剂提取后采用选择性离子检测方法测定其血药浓度，10％Na2S2O5溶液作为酶抑制剂。结果：特布它林的线性范围为0.1ng/ml-20.0ng/ml，日内和日间精密度均小于15．0％，方法的加收率为79％－90％。结论：该测定方法学考察均符合血浆样品的要求，可以运用于临床药物动力学研究。

Abstract: AIM A highly sensitive and specific method for the determination of terbutaline in human plasma by LC MS was developed after administration of its prodrug Bambuterol. METHODS\ Terbutaline was extracted from human plasma and analyzed by LC MS via an