维生素B12溶液鼻粘膜吸收的研究

Studies on Nasal Absorption of Vitamin B_(12) Solution

摘要: 目的：研究维生素B12溶液鼻粘膜吸收规律。方法：以大鼠在体鼻循环法为实验模型，考查循环液浓度不同时，维生素B12鼻粘膜吸收规律。结果：考察了0.25,0.5,1mg/ml三种浓度的维生素B12溶液鼻粘膜吸收规律，表明不同浓度的维生素B12鼻粘膜吸收速度为一常数。结论：维生素B12溶液鼻粘膜吸收机制为被动扩散，吸收符合一级动力学，吸收速度常数K为0．02441min^-1。

Abstract: AIM The purpose is to investigate the regulation of vitamin B 12 nasal absorption. METHODS Rat in situ nasal recirculation mathods as experimental model were used. The effects of perfusion concentration on nasal absorption of vitamin B 12 were