抗前列腺增生药SL—89．0519—08的合成
Synthesis of SL-89.0519-08
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摘要: 目的：研究治疗前列腺增生的α1－受体拮抗剂SL－89．0519－08的合成路线。方法：以5－氯－2－甲氧基苯胺为原料，经环合，烃化，脱保护基和亲核取代等步骤，合成了目标化合物，同时对原料合成工艺进行了摸索。结果：合成的目标化合物经IR，^1HMNR,EI-MS和HRMS得以确证。结论：该合成工艺和路线适宜工业化生产。Abstract: AIM The purpose is to make a research of synthetic scheme of adrenergic antagonist SL 89.0519 08 for the treatment of benign prostatic hyperplasia. METHODS Using 5 chloro 2 methoxyaniline, the target compound was synthesized after steps of cycliza
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