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瑞香苷对高尿酸血症小鼠的影响[J]. 中国药科大学学报, 2002, (2): 64-67.
引用本文: 瑞香苷对高尿酸血症小鼠的影响[J]. 中国药科大学学报, 2002, (2): 64-67.
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Effects of Daphnin on Serum Uric Acid Level in in vivo Model of Hyperuricemic Mice[J]. Journal of China Pharmaceutical University, 2002, (2): 64-67.
Citation: Effects of Daphnin on Serum Uric Acid Level in in vivo Model of Hyperuricemic Mice[J]. Journal of China Pharmaceutical University, 2002, (2): 64-67.
shu

瑞香苷对高尿酸血症小鼠的影响

Effects of Daphnin on Serum Uric Acid Level in in vivo Model of Hyperuricemic Mice

    摘要
  • 摘要: 目的；研究瑞香苷对高尿酸血症小鼠血清尿酸水平的影响。方法：选择化学诱导剂氧嗪酸钾盐作为尿酸酶抑制剂，小鼠腹腔注射后造成高尿酸血症模型，采用磷钼酸还原法测定小鼠血清尿酸水平。结果：腹腔注射瑞香苷（50，100和200mg/kg)能显著地减少高尿酸血症小鼠血清尿酸水平，具有一定的量效关系。瑞香苷100mg/kg剂量组作用时间可维持5h。瑞香苷在剂量为200mg／kg时可降低正常小鼠血清尿酸水平。结论：瑞香苷对高尿酸血症小鼠具有明显降低血清尿酸水平作用。

     

    Abstract: AIM The purpose is to study hypouricemic effect of daphnin on serum uric acid level in hyperuricemic mice. METHODS The uricase inhibitor potassium oxonate was used to induce in \%in vivo\% model of hyperuricemia in mice. Serum uric acid level was dete

     

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