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盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨[J]. 中国药科大学学报, 2002, (3): 42-44.
引用本文: 盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨[J]. 中国药科大学学报, 2002, (3): 42-44.
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Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character[J]. Journal of China Pharmaceutical University, 2002, (3): 42-44.
Citation: Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character[J]. Journal of China Pharmaceutical University, 2002, (3): 42-44.
shu

盐酸维拉帕米自乳化缓释片的研制及释药行为的探讨

Development of Verapamil Hydrochloride Self-Emulsifying Sustained-Release Tablets and Exploration of Released Character

    摘要
  • 摘要: 目的：探索固体自乳化释放药系统，研制自乳化缓释片，考察体外释药行为。方法：以盐酸维拉帕米（Verpamil Hydrochloride,VH)为模型药物，以吐温80（Tween80），豆磷脂（sbpc)为乳化剂，以羟丙甲纤维素（HPMC），卡波普（carbopol)为骨架材料，制备自乳化缓释片。结果：以含吐温80和豆磷脂10％，羟丙甲纤维素和卡波普30％的处方乳化效果好，体外释药符合要求。结论：通过调节乳化剂和骨架材料的比例，可以获得理想的自乳化固体缓释制剂。

     

    Abstract: AIM Self emulsifying drug delivery systems were studied. Verapamil Hydrochloride self emulsifying sustained release tablets were developed and evaluated \%in vitro\% release characteristics. METHODS The Verapamil Hydrochloride formulations were scre

     

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