四氢小檗碱的拆分

Resolution of Tetrahydroberberine

摘要: 目的通过化学拆分得到四氢小檗碱的光学异构体。方法四氢小檗碱由小檗碱制备，以（-）/（）二对甲苯甲酰酒石酸为拆分剂对其进行拆分。结果拆分所得的（-）/（）四氢小檗碱旋光值与文献报道一致。结论通过化学拆分成功地获得了（-）/（）四氢小檗碱。
- 四氢小檗碱 /
- 二对甲苯甲酰酒石酸 /
- 拆分 /
- 手性药物
Abstract: AIM The purpose is to resolute tetrahydroberberine.METHODS Tetrahydroberberine was synthesized from berberine chloride,then resoluted with (+) /(-) di - o,o,-p -toluyl-tartaric acid which was prepared from D/L -tartaric acid.RESULTS AND CONCLUTION S
- Tertrahydroberberine /
- (+) /(-)Di- o,o,-p -toluyl-tartaric acid /
- Resolution