半夏厚朴汤抗抑郁作用的研究—Ⅰ

Department of Pharmacology of the Traditional Chinese Medicine,China Pharmaceutical University,Nanjing 210038, Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China

摘要: 目的研究半夏厚朴汤的抗抑郁作用。方法采用小鼠强迫游泳，悬尾，育亨宾增强，高剂量阿扑吗啡拮抗等实验动物模型。评价半夏厚朴汤的抗抑郁作用。结果半夏厚朴汤200，500mg/kg能显著缩短小鼠强迫游泳，悬尾不动时间，50，200，500mg/kg能增强育亨宾对小鼠的毒性作用。500mg/kg能拮抗阿扑吗啡降低小鼠体温作用。结论半夏厚朴汤具有显著的抗抑郁作用。
- 半夏厚朴汤 /
- 抗抑郁 /
- 动物模型 /
- 育亨宾 /
- 阿扑吗啡 /
- 拮抗 /
- 抑郁症
Abstract: AIM The purpose is to study the antidepressant effect of Banxiahouputang on animal models. METHODS The antidepressant effect of Banxiahouputang was evaluated through mice forced swimming test, mice tail suspension test,and antagonism of high dose of apo
- Banxiahouputang /
- Antidepressant /
- Animal models /
- Yohimbine /
- Apomorphine