盐酸洛美利嗪的NMR研究

NMR Studies on Lomerizine Dihydrochloride

摘要: 目的研究盐酸洛美利嗪在DMSO-d6溶剂中的核磁共振现象并对其质子和碳信号进行归属。方法测定其在改变温度和加入重水条件下的各种1D和2D核磁共振谱。结果室温下以DMSO-d6为溶剂时，哌嗪环及与其相连的碳，氢均呈现多个峰或宽峰，提高温度或加入重水后，其碳，氢信号均出现“合并”或变窄现象。结论室温下在DMSO-d6溶剂中，不同构象的盐酸洛美利嗪同时并存。随着温度的提高或加入重水，则逐渐变为单一并且稳定的构象。

Abstract: AIM To investigate the NMR phenomena of lomerizine dihydrochloride and to assign all proton as well as carbon signals in the NMR spectra. METHODS Recording the 1D and 2D NMR spectra of lomerizine dihydrochloride while changing the experimental temperatu