香豆素磺酰脲类化合物的降血糖作用研究
Hypoglycemic Effect of Coumarin-6-Sulfonylureas
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摘要: 目的:对香豆素磺酰脲类化合物的降糖作用进行初步筛选;测定10个香豆素磺酰脲化合物的药效学参数。方法:正常小鼠灌胃给药后,毛细玻管取血,用葡萄糖测定法(GOD—PAP)测定血糖。结果和结论:初步药理实验表明SU—111,SU—118,SU—611,C6,SU—614,SU—615,SU—616等有明显降糖作用;测定了10个香豆素磺酰脲类化合物对正常小鼠降血糖作用的药效学参数,并用于构效关系分析。
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关键词:
- 香豆素磺酰服类化合物 /
- 降血糖作用 /
- 构效关系 /
- 小鼠
Abstract: The purpose is to study the effect on serum glucose by giving diff erent coumarin 6 sulfonylurea compounds. Serum glucose of normal mice were determined after giving coumarin 6 sulfonyl urea compounds (50 mg/kg, ig) Results showed that the drugs inc -
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