褪黑素缓释片的研制及释药特性的研究
Development of Melatonin Sustained-Release Tablets and Exploration of Release Character
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摘要: 目的：研制凝胶骨架型褪黑素缓释片，考察其体外释药特性。方法：以羟丙基甲基纤维素(HPMCK4M)为骨架材料，根据设计的体外释药速率，筛选处方。结果：药物释放是骨架溶蚀和药物扩散的综合效应，释药速率不受pH环境的影响，受压片压力的影响，受机械搅动影响较小。结论：本文研制的褪黑素缓释片成型性好，具有工艺重现性，体外释放符合拟定的释药速率。Abstract: AIM:Melatonin sustained-release tablets were developed as a gel matrix and evaluated in vitro release characteristics. METHOD:The formulations were screened according to the designed in vitro release rate by the use of HPMC as the gel matrix to modify the
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