溴芬酸钠的合成

溴芬酸钠的合成[J]. 中国药科大学学报, 2003, (5): 19-20.

引用本文:

溴芬酸钠的合成[J]. 中国药科大学学报, 2003, (5): 19-20.

Synthesis of Bromfenac Sodium[J]. Journal of China Pharmaceutical University, 2003, (5): 19-20.

Citation:

Synthesis of Bromfenac Sodium[J]. Journal of China Pharmaceutical University, 2003, (5): 19-20.

Synthesis of Bromfenac Sodium

摘要: 目的：对专利合成溴芬酸钠路线进行改进。方法：以对溴苯甲腈和吲哚啉为原料，经硫化、氧化、氯化、酸水解、碱水解开环生成溴芬酸钠。结果：总收率为28．8％。结论：工艺适合于生产。

Abstract: AIM:To develope the synthesis route of bromfenac.METHOD:Bromfenac sodium was prepared from p -bromobenzonitrile and indoline.RESULT:The total yield was 28.8%. CONCLUSION:This synthesis route is applicable for large sale production.

用微信扫码二维码

分享至好友和朋友圈