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布地奈德结肠定位微丸的制备及释药特性研究[J]. 中国药科大学学报, 2003, (5): 33-36.
引用本文: 布地奈德结肠定位微丸的制备及释药特性研究[J]. 中国药科大学学报, 2003, (5): 33-36.
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Study on the Preparation and Drug Release of Controled-Release Micropellets for Budesonide Colon Specific Delivery[J]. Journal of China Pharmaceutical University, 2003, (5): 33-36.
Citation: Study on the Preparation and Drug Release of Controled-Release Micropellets for Budesonide Colon Specific Delivery[J]. Journal of China Pharmaceutical University, 2003, (5): 33-36.
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布地奈德结肠定位微丸的制备及释药特性研究

Study on the Preparation and Drug Release of Controled-Release Micropellets for Budesonide Colon Specific Delivery

    摘要
  • 摘要: 目的：制备pH-时滞型布地奈德微丸并对其释药特性进行研究。方法：采用锅包衣法制备裁药微丸，并进行乙基纤维素有机溶液包衣及Eudragit FS30D水分散体包衣。用转篮法进行释放度实验，采用多种pH模式筛选和评价处方。结果与结论：包衣厚度及材料比和pH对释药速率均有影响。优选处方微丸在高低2种pH模式下，其释药特性符合设计要求。

     

    Abstract: AIM: The aim of the present study was to develop a pH-dependent and controled-release micropellets of budesonide and to evaluate their in vitro release. METHODS: The drug loaded pellets were prepared and then coated with organic solution of EC and an new

     

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