柔性纳米脂质体对皮肤角质层结构的改变
Structural Change of Stratum Corneum by Flexible Nano-liposomes
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摘要: 目的:研究柔性纳米脂质体对皮肤角质层结构的改变.方法:将等渗磷酸盐缓冲液(pH 7.4)、柔性纳米脂质体、胆酸钠溶液分别应用于人离体皮肤角质层和小鼠在体皮肤表面,应用扫描电镜观察角质层的结构.结果:离体条件下,柔性纳米脂质体处理过的人角质层,角质细胞间隙明显增宽.在体条件下,小鼠皮肤表面无显著性差异.结论:离体条件下,柔性纳米脂质体在角质层中的转运可能以融合扩散为主,在体条件下以穿透机制为主,且并不改变皮肤结构.Abstract: AIM:To discover the structure change of stratum corneum with flexible nanoliposome METHOD:Isotonic phosphate buffer(pH 7 4),flexible nanoliposome and sodium cholate solution were respectively applied to cadaver stratum corneum and the mice skin Scan
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