Abstract:
Aim :To study
in vitro anti-HIV activities of [Ln(Phen)
2 (5-Fu)
3 (NO
3)](NO
3)
2.
Methods :Seven kinds of [Ln(Phen)
2 (5-Fu)
3 (NO
3)](NO
3)
2complexes (Ln=Y,La,Ce,Sm,Gd,Dy,Er;Phen=1,10-phenanthroline;5-Fu=fluorouracil) were tested for their potential anti-HIV activities.IC
50 of the complexes on C8166 cells was assayed by colorimetric MTT.EC
50 was determined through the inhibition of syncytia formation induced by H9/HIV-1
IIIB.The therapeutic index (TI,IC
50/EC
50) were calculated and compared with that of azidothymidine (AZT).
Results :It was found that TI of [La(Phen)
2 (5-Fu)
3 (NO
3)](NO
3)
2 and[Ce(Phen)
2 (5-Fu)
3 (NO
3)](NO
3)
2 were 68.03 and 33.13,respectively.
Conclusion :La or Ce doped complexes demonstrated
in vitro anti-HIV activity.