阿昔洛韦缓释片的体外和体内实验研究

Study of Acyclovir Sustained Release Tablets in vitro and in vivo

摘要: 研制阿昔洛韦缓释片，并对其体外释放特点和初步的体内过程进行了研究。分别采用紫外分光光度法和高效液相色谱荧光检测法对阿昔洛韦进行体外释放度和体内血药浓度测定。采用４例志愿者单剂量口服缓释片和市售片，测定血药浓度并计算药动学参数。该缓释片在体外和体内均具有缓释作用，与参比制剂比较，服用缓释片组血药浓度较为平稳和持久，ＡＵＣ增大，峰浓度降低，达峰时间延长。
- 阿昔洛韦 /
- 缓释片 /
- 药动学 /
- 抗病毒药 /
- 实验研究
Abstract: Acyclovir(ACV) sustained release tablets(SRT) were prepared. The releasing characteristics in vitro and the pharmacokinetics in vivo were studied primitively. UV method was established for assaying release of SRT in vitro . The HPLC fluorescen
- Acyclovir /
- Sustained release tablets /
- Pharmacokinetics /
- \%In vitro /
- In vivo\%