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MA Xiaoping, XU Ying, DING Jie, LIN Na. Effects of estradiol valerate on the estrogen receptor expression in uterus, vagina and mammary gland of ovariectomized rats[J]. Journal of China Pharmaceutical University, 2014, 45(3): 341-345. DOI: 10.11665/j.issn.1000-5048.20140316
Citation: MA Xiaoping, XU Ying, DING Jie, LIN Na. Effects of estradiol valerate on the estrogen receptor expression in uterus, vagina and mammary gland of ovariectomized rats[J]. Journal of China Pharmaceutical University, 2014, 45(3): 341-345. DOI: 10.11665/j.issn.1000-5048.20140316
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Effects of estradiol valerate on the estrogen receptor expression in uterus, vagina and mammary gland of ovariectomized rats

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  • The objective of this study was to evaluate the effects of estradiol valerate(EV)on the estrogen receptor expression and the pathological changes of tissues in uterus, vagina and breast of ovariectomized rats, and investigate the estrogen-like mechanism. HE method was used to determine the tissue pathological changes; the protein expression levels of estrogen receptor alpha(ERα)and estrogen receptor beta(ERβ)in mammary gland, uterus and vagina were detected by immunohistochemistry and Western blot. The results indicated that estradiol valerate could obviously antagonize the atrophy of the target organs in ovariectomized rats, and the up-regulated expression of the estrogen receptors in target organs is the possible mechanism of EV induced estrogenic activity.
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    • References (12)
  • [1]
    Teichmann A.Pharmacology of estradiol valerate/dienogest[J].Climacteric,2003,6(Suppl 2):17-23.
    [2]
    Blode H,Zeun S,Parke S,et al.Evaluation of the effects of rifampicin,ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women[J].Contraception,2012,86(4):337-344.
    [3]
    Noorafshan A,Ahmadi M,Mesbah SF,et al.Stereological study of the effects of letrozole and estradiol valerate treatment on the ovary of rats[J].Clin Exp Reprod Med,2013,40(3):115-112.
    [4]
    Rafie S,Borgelt L,Koepf ER,et al.Novel oral contraceptive for heavy menstrual bleeding:estradiol valerate and dienogest[J].Int J Womens Health,2013,5:313-321.
    [5]
    Wiegratz I,Lee JH,Kutschera E,et al.Effect of four oral contraceptives on hemostatic parameters[J].Contraception,2004,70(2):97-106.
    [6]
    Brawer JR,Munoz M,Farookhi R.Development of the polycystic ovarian condition(PCO)in the estradiol valerate-treated rat[J].Biol Reprod,1986,35(3):647-655.
    [7]
    Shi D,Vine DF.Animal models of polycystic ovary syndrome:a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk[J].Fertil Steril,2012,98(1):185-193.
    [8]
    Yuan BJ,Wang QZ.Preclinical Safety Evaluation of New Drugs and Practice[M].Beijing:Military Medical Science Press,1997:125-136.
    [9]
    Lin H,Zang W,Zheng YL,et al.Early pregnancy supplement for male offspring rats estradiol valerate affect the reproductive system development[J].Natl J Androl(中华男科学杂志),2009, 15(9):779-782.
    [10]
    Couse JF,Korach KS.Reproductive phenotypes in the estrogen receptor-alpha knockout mouse[J].Ann Endocrinol(Paris),1999,60(2):143-148.
    [11]
    Hewitt SC,Korach KS.Oestrogen receptor knockout mice:roles for oestrogen receptors alpha and beta in reproductive tissues[J].Reproduction,2003,125(2):143-149.
    [12]
    Rimoldi G,Christoffel J.Effects of chronic genistein treatment in mammary gland,uterus,and vagina[J].Environ Health Perspect,2007,115(Suppl 1):62-68.
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