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SHANG Ying, ZHAO Liyuan, LU Jingkun. Relationship between inflammatory cytokines and gastric cancer[J]. Journal of China Pharmaceutical University, 2015, 46(1): 123-128. DOI: 10.11665/j.issn.1000-5048.20150119
Citation: SHANG Ying, ZHAO Liyuan, LU Jingkun. Relationship between inflammatory cytokines and gastric cancer[J]. Journal of China Pharmaceutical University, 2015, 46(1): 123-128. DOI: 10.11665/j.issn.1000-5048.20150119
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Relationship between inflammatory cytokines and gastric cancer

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    • Abstract
  • Inflammatory cytokines are closely related to the development of gastric cancer. Pro-inflammatory cytokines, anti-inflammatory cytokines and their associated signaling pathways play different roles on the stages of gastric cancer, such as occurrence, development and prognosis, through different channels. This article summarizes the expression and function of Helicobacter pylori, IL-1β, TNF-α, IL-8, TGF-β, IL-10, IL-18 and T lymphocytes in gastric tissue or blood. The inflammatory cytokines and their associated signaling pathways which working as therapeutic targets for gastric cancer are also concluded.
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  • [1]
    Guggenheim DE,Shah MA.Gastric cancer epidemiology and risk factors[J].J Surg Oncol,2013,107(3):230-236.
    [2]
    Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
    [3]
    Ferro A,Peleteiro B,Malvezzi M,et al.Worldwide trends in gastric cancer mortality(1980-2011),with predictions to 2015,and incidence by subtype[J].Eur J Cancer,2014,50(7):1330-1344.
    [4]
    Shi YY,Ding SG.Progress in the etiology and pathogenesis of gastric cancer[J].Chin J Clinicians(Electron Ed)(中华临床医师杂志 电子版),2013,7(19):7941-7944.
    [5]
    Nam SY,Ko YS,Jung J,et al.A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis[J].Br J Cancer,2011,104(1):166-174.
    [6]
    Kang MH,Oh SC,Lee HJ,et al.Metastatic function of BMP- 2 in gastric cancer cells:the role of PI3K/AKT,MAPK,the NF-κB pathway,and MMP-9 expression[J].Exp Cell Res,2011,317(12):1746-1762.
    [7]
    Okamoto W,Okamoto I,Arao T,et al.Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells[J].Br J Cancer,2011,105(3):407-412.
    [8]
    Chen J,Wang J,Lin L,et al.Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer[J].Mol Cancer Ther,2012,11(2):277-287.
    [9]
    Xiong H,Du W,Wang JL,et al.Constitutive activation of STAT3 is predictive of poor prognosis in human gastric cancer[J].J Mol Med(Berl),2012,90(9):1037-1046.
    [10]
    Carmi Y,Dotan S,Rider P,et al.The role of IL-1β in the early tumor cell-induced angiogenic response[J].J Immunol,2013,190(7):3500-3509.
    [11]
    Poeck H,Bscheider M,Gross O,et al.Recognition of RNA virus by RIG-I results in activation of CARD9and inflammasome signaling for interleukin 1 beta production[J].Nat Immunol,2010,11(1):63-69.
    [12]
    Santos JC,Ladeira MS,Pedrazzoli J Jr,et al.Relationship of IL-1 and TNF-α polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population[J].Braz J Med Biol Res,2012,45(9):811-817.
    [13]
    Martinez-Carrillo DN,Garza-Gonzalez E,Betancourt-Linares R,et al.Association of IL1B-511C/-31T haplotype and Helicobacter pylori vacA genotypes with gastric ulcer and chronic gastritis[J].BMC Gastroenterol,2010,10:126.
    [14]
    Xue H,Lin B,Ni P,et al.Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk:a meta-analysis[J].J Gastroenterol Hepatol,2010,25(10):1604-1617.
    [15]
    Bonequi P,Meneses-González F,Correa P,et al.Risk factors for gastric cancer in Latin America:a meta-analysis[J].Cancer Causes Control,2013,24(2):217-231.
    [16]
    Gilmore TD.Introduction to NF-KB:players,pathways,perspective[J].Oncoqene,2006,25(51):6680-6684.
    [17]
    Canedo P,Durães C,Pereira F,et al.Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma[J].Cancer Epidemiol Biomarkers Prev,2008,17(9):2416-2420.
    [18]
    Li DB.Detection and significance of TNF-a and IL-8 in gastric cancer patients serum[J].J Changzhi Med Coll(长治医学院学报),2010,24(6):404-407.
    [19]
    Melo Barbosa HP,Martins LC,Dos Santos SE,et al.Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population[J].World J Gastroenterol,2009, 15(12):1465-1471.
    [20]
    Rokkas T,Sechopoulos P,Pistiolas D,et al.Population differences concerning TNF-α gene polymorphisms in gastric carcinogenesis based on meta-analysis[J].Ann Gastroenterol,2014,27(2):139-148.
    [21]
    Kuai WX,Wang Q,Yang XZ,et al.Interleukin-8 associates with adhesion,migration,invasion and chemosensitivity of human gastric cancer cells[J].World J Gastroenterol,2012, 18(9):979-985.
    [22]
    Yamada S,Kato S,Matsuhisa T,et al.Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer[J].World J Gastroenterol,2013,19(19):2941-2949.
    [23]
    Gabellini C,Trisciuoglio D,Desideri M,et al.Functional activity of CXCL8 receptors,CXCR1 and CXCR2,on human malignant melanoma progression[J].Eur J Cancer,2009,45(14):2618-2627.
    [24]
    Kitadai Y,Haruma K,Mukaida N,et al.Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8[J].Clin Cancer Res,2000,6(7):2735-2740.
    [25]
    Christofakis EP,Miyazaki H,Rubink DS,et al.Roles of CXCL8 in squamous cell carcinoma proliferation and migration[J].Oral Oncol,2008,44(10):920-926.
    [26]
    Wu S,Shang H,Cui L,et al.Targeted blockade of interleukin-8 abrogates its promotion of cervical cancer growth and metastasis[J].Mol Cell Biochem,2013,375(1/2):69-79.
    [27]
    Martin D,Galisteo R,Gutkind JS.CXCL8/IL8 stimulates vascular endothelial growth factor(VEGF)expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM(Carma3/Bcl10/Malt1)complex[J].J Biol Chem,2009,284(10):6038-6042.
    [28]
    Li A,Dubey S,Varney ML,et al.IL-8 directly enhanced endothelial cell survival,proliferation,and matrix metalloproteinases production and regulated angiogenesis[J].J Immunol,2003,170(6):3369-3376.
    [29]
    Cai X,Hu W,Zhang B,et al.Genotyping of IL-8-251 T>A yields prognostic information in patients with gastric carcinoma[J].Biomarkers,2013,18(7):559-564.
    [30]
    Song JH,Kim SG,Jung SA,et al.The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans[J].Cytokine,2010,51(2):158-165.
    [31]
    Fabris RC,Rasmussen LT,Neto AC,et al.Interleukin-8-251 T>A polymorphism and Helicobacter pylori[J].Arq Catar Med,2012,40(3):25-29.
    [32]
    Cheng HH,Chang CS,Wang HJ,et al.Interleukin-1β and -10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients[J].J Gastroenterol Hepatol,2010,25(8):1443-1451.
    [33]
    Wang N,Zhou R,Wang C,et al.-251 T/A polymorphism of the interleukin-8 gene and cancer risk:a HuGE review and meta-analysis based on 42 casecontrol studies[J].Mol Biol Rep, 2012,39(3):2831-2841.
    [34]
    Derynck R,Miyazono K.The TGF-β Family[M].NY:Cold Spring Harbor Laboratory Press,2008:29-43.
    [35]
    Derynck R,Akhurst RJ.Differentiation plasticity regulated by TGF-beta family proteins in development and disease[J].Nat Cell Biol,2007,9(9):1000-1004.
    [36]
    Kamato D,Burch ML,Piva TJ,et al.Transforming growth factor-β signalling:role and consequences of Smad linker region phosphorylation[J].Cell signal,2013,25(10):2017-2024.
    [37]
    Jo Y,Han SU,Kim YJ,et al.Suppressed gastric mucosal TGF-β1 increases susceptibility to H.pylori-induced gastric inflammation and ulceration:a stupid host defense response[J].Gut Liver,2010,4(1):43-53.
    [38]
    Yuan XL,Chen L,Zhang TT,et al.Gastric cancer cells induce human CD4+Foxp3+ regulatory T cells through the production of TGF-β1[J].World J Gastroenterol,2011,17(15):2019-2027.
    [39]
    Lv ZD,Na D,Liu FN,et al.Induction of gastric cancer cell adhesion through transforming growth factor-beta1-mediated peritoneal fibrosis[J].J Exp Clin Cancer Res,2010,29(1):139.
    [40]
    Mocellin S,Marincola FM,Young HA.Interleukin-10 and the immune response against cancer:a counterpoint[J].J Leukoc Biol,2005,78(5):1043-1051.
    [41]
    Bodger K,Wyatt JI,Heatley RV.Gastric mucosal secretion of interleukin-10:relations to histopathology,Helicobacter pylori status,and tumour necrosis factor-alpha secretion[J].Gut,1997,40:739-744.
    [42]
    De Vita F,Orditura M,Galizia G,et al.Serum interleukin-10 levels in patients with advanced gastrointestinal malignancies[J].Cancer,1999,86(10):1936-1943.
    [43]
    Ono S,Tsujimoto H,Hiraki S,et al.Sex differences in cytokine produetion and surface antigen expression of peripheral blood mononuclear cells after surgery[J].Am J Surg,2005,190(3):439-44.
    [44]
    Liu J,Song B,Wang JL,et al.Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer[J].World J Gastroenterol,2011,17(10):1362-1367.
    [45]
    Zhuang W,Wu XT,Zhou Y,et al.Interleukin10-592 promoter polymorphism associated with gastric cancer among Asians:a meta-analysis of epidemiologic studies[J].Dig Dis Sci,2010,55(6):1525-1532.
    [46]
    Chiurillo MA.Role of gene polymorphisms in gastric cancer and its precursor lesions:current knowledge and perspectives in Latin American countries[J].World J Gastroenterol,2014,20(16):4503-4515.
    [47]
    Con SA,Takeuchi H,Con-Chin GR,et al.Role of bacterial and genetic factors in gastric cancer in Costa Rica[J].World J Gastroenterol,2009,15(2):211-218.
    [48]
    de Oliveira JG,Rossi AF,Nizato DM,et al.Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer[J].Dig Dis Sci,2013,58(4):978-988.
    [49]
    Li W,Yang Z,Huang DQ,et al.Role of Th17 and IL-17 in Helicobacter pylori-related gastric carcinogenesis[J].World Chin J Dig(世界华人消化杂志),2011,20(11):936-940.
    [50]
    Tomita T,Jackson AM,Hida N,et al.Expression of interleukin-18,a Th1 cytokine,in human gastric mucosa is increased in Helicobacter pylori infection[J].J Infect Dis,2011,183(4):620-627.
    [51]
    Fang RG,Wang JJ,Wang XJ,et al.Expression of IL-18 in gastric cancer and its clinical significance[J].J Chin Oncol(肿瘤学杂志),2012,18(5):333-335.
    [52]
    Li AL,Hu ZF,Niu CY,et al.Correlation between IL-18 gene 105A/ C polymorphism and gastric cancer[J].Chin J Gerontol(中国老年学杂志),2014,34(8):2074-2076.
    [53]
    Mitchell PJ,Afzali B,Fazekasova H,et al. Helicobacter pylori induces in-vivo expansion of human regulatory T cells through stimulating interleukin-1β production by dendritic cells[J].Clin Exp Immunol,2012,170(3):300-309.
    [54]
    Jiang L,Fei XM,Ruan JS,et al.Chemotherapy on cellular immune function in patients with lung cancer[J].Zhejiang Pract Med(浙江实用医学),2013,18(6):439-442.
    [55]
    Jiang H,Li JX.T lymphocyte subsets in peripheral blood of cancer patients[J].Lab Med Clin(检验医学与临床),2010,7(13):1361.
    [56]
    Chen ZY,Li J.Phase targeted therapies in the treatment of gastric cancer[J].China Oncol(中国癌症杂志),2006,16(1):67-71.
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