• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
XIE Weina, DING Qi, SUN Jing, ZHANG Chaofeng, ZHANG Mian, XU Xianghong. Protective effects of Baibu Tang on bleomycin-induced pulmonary fibrosis in mice[J]. Journal of China Pharmaceutical University, 2018, 49(4): 483-489. DOI: 10.11665/j.issn.1000-5048.20180415
Citation: XIE Weina, DING Qi, SUN Jing, ZHANG Chaofeng, ZHANG Mian, XU Xianghong. Protective effects of Baibu Tang on bleomycin-induced pulmonary fibrosis in mice[J]. Journal of China Pharmaceutical University, 2018, 49(4): 483-489. DOI: 10.11665/j.issn.1000-5048.20180415
shu

Protective effects of Baibu Tang on bleomycin-induced pulmonary fibrosis in mice

More Information
    Graphical Abstract
    • Abstract
  • This study aimed to investigate the protective effects of Baibu Tang on bleomycin-induced pulmonary fibrosis in mice. After intratracheally giving bleomycin(3. 5 mg/kg), mice were orally administered Baibu Tang once a day for 14 consecutive days, takingnintedanib as a positive control. The anti-fibrotic effects were assessed by the hydroxyproline level and the histopathological changes in H&E or Masson stained lung tissues. The results revealed that the lung coefficient, hydroxyproline content, inflammation and collagen deposition were increased significantly in the lung tissue of the model mice. Both ethanol and water extracts of Baibu Tang significantly improved all the pathological indexes in mice, but the effect of the ethanol extract was better than that of the water extract. Baibu Tang with Baibu(root of Stemona tuberosa)containing different components(neotuberostemonine, tuberostemonine and stemoninine, respectively)could significantly reduce hydroxyproline level and collagen deposition in the lung tissue of bleomycin-induced mice, and there was no significant difference in their activity. This result showed that the changes in the chemical composition of Stemona tuberosa(Baibu, monarch drug for Baibu Tang)have little effect on the anti-fibrosis activity of Baibu Tang, and its mechanism and material basis need further investigation.
    • FullText(HTML)
    • References (16)
  • [1]
    Liang JR,Zhang YL,Xie T,et al.Hyaluronan and TLR4 promote surfactant protein C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice[J].nat Med,2016,22(11):1285-1293.
    [2]
    Park S,Lee EJ.Recent advances in idiopathic pulmonary fibrosis[J].Tuberc Respir Dis(Seoul),2013,74(1):1-6.PH
    [3]
    Divya T, Dineshbabu V, Soumyakrishnan S, et al. Celastrol enhances nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis[J].Chem Biol Interact,2016,246:52-62.
    [4]
    Hillary LK,Flaherty KR,Moore BB.Pathogenesis,current treatments and future directions for idiopathic pulmonary fibrosis[J].Curr Opin Pharmacol,2013,13(3):377-385.
    [5]
    Spagnolo P, Maher TM, Richeldi L. Idiopathic pulmonary fibrosis:recent advances on pharmacological therapy[J].Pharmacol Therapeut,2015,152:18-27.
    [6]
    Yang L,Lv XD,Liu YM,et al.Research progress on the mechanism of oxidative stress in traditional Chinese medicine on prevention and treatment of pulmonary fibrosis[J].World J Integr Tradit West Med(世界中西医结合杂志),2017,12(3):297-300.
    [7]
    Chinese Pharmacopoeia Commission.Pharmacopoeia of the People’s Republic of China(Vol 1)(中华人民共和国药典,一部)[S].Beijing:China Medical Science Press,2015:132.
    [8]
    Wang ZW,Yang PL,Shen L,et al.Clinical study of BaiBu YangFei Decocted Extract in the treatment for COPD patients at stable stage[J].West J Tradit Chin Med(西部中医药),2015,28(5):56-59.
    [9]
    Li R,Zhang Y,Chen YR.Clinical analysis of 38 cases of pulmonary fibrosis treated by tonifying kidney and activating meridians[J].J Mod Clin Med(现代临床医学),2014,40(4):285-287.
    [10]
    Xu YT,Hon PM,Jiang RW,et al.Antitussive effects of Stemona tuberosa with different chemical profiles[J].J Ethnopharmacol,2006,108(1):46-53.
    [11]
    Jiang RW,Hon PM,Zhou Y,et al.Alkaloids and Chemical Diversity of Stemona tuberosa[J].Jnat Prod,2006,69(5):749-754.
    [12]
    Hillary LK,Flaherty KR,Moore BB.Pathogenesis,current treatments and future directions for idiopathic pulmonary fibrosis[J].Curr Opin Pharmacol,2013,13(3):377-385.
    [13]
    Huang YJ,Gong JN.Analysis on pulmonary fibrosis ofname,pathogenesis,syndromes and treatment[J].J Liaoning Univ TCM(辽宁中医药大学学报),2016,18(9):98-100.
    [14]
    Gong T,Yan DD,Dou YC,et al.Research progress of traditional Chinese medicine for pulmonary fibrosis[J].J Shandong Univ TCM(山东中医药大学学报),2016,40(6):579-582.
    [15]
    Xiang J,Yu P,Li MD,et al.Protective effects of stemona alkaloids on mice with bleomycin-induced pulmonary fibrosis[J].J China Pharm Univ(中国药科大学学报),2017,48(1):76-81.
    [16]
    Xiang J,Cheng S,Feng TL,et al.neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages[J].Int Immunopharmacol,2016,36(7):158-164.
    • Related Articles

  • Related Articles

    [1]QIAN Xiuhui, SUN Jing, FU San, TANG Xiaoyan, XU Xianghong, ZHANG Mian. Effect of intratracheal instillation of PM2.5 suspensionon pulmonary fibrosis in mice and the intervention of neotuberostemonine[J]. Journal of China Pharmaceutical University, 2021, 52(4): 455-462. DOI: 10.11665/j.issn.1000-5048.20210408
    [2]FANG Daqing, LIU Fang, ZHANG Sijia, CAI Chaoqun, LIU Minzhuo, LIU Jinghan, YANG Chunhua, WANG Hao. One new diterpenoid alkaloid from Aconitum carmichaeli[J]. Journal of China Pharmaceutical University, 2017, 48(5): 568-571. DOI: 10.11665/j.issn.1000-5048.20170510
    [3]XIANG Juan, YU Ping, LI Mingdan, ZHANG Chaofeng, XU Xianghong, ZHANG Mian. Protective effects of stemona alkaloids on mice with bleomycin-induced pulmonary fibrosis[J]. Journal of China Pharmaceutical University, 2017, 48(1): 76-81. DOI: 10.11665/j.issn.1000-5048.20170112
    [4]YAO Juan, XIONG Fei, ZHU Zi-yi, LIU Jian-ping, GU Ning. Preparation and in vitro evaluation of vincristine-loaded superparamagnetic iron oxide nanoparticles[J]. Journal of China Pharmaceutical University, 2012, 43(3): 222-225.
    [5]Comparative pharmacokinetics of aconitine, mesaconitine and hypaconitine in rats after oral administration of four decoctions composed with Radix Aconiti Lateralis[J]. Journal of China Pharmaceutical University, 2010, 41(1): 55-59.
    [10]POLLEN MORPHOLOGY IN CHINESE SPECIES OF STEMONA[J]. Journal of China Pharmaceutical University, 1989, (6): 325-329.

Catalog

    Get Citation
    PDF
    XML
    Article views (1245) PDF downloads (1404) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：300505

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return