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LU Xinyue, LYU Huixia. Research advances in materials for microspheres as drug delivery system[J]. Journal of China Pharmaceutical University, 2018, 49(5): 528-536. DOI: 10.11665/j.issn.1000-5048.20180503
Citation: LU Xinyue, LYU Huixia. Research advances in materials for microspheres as drug delivery system[J]. Journal of China Pharmaceutical University, 2018, 49(5): 528-536. DOI: 10.11665/j.issn.1000-5048.20180503

Research advances in materials for microspheres as drug delivery system

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  • Microsphere as a drug delivery system with broad prospect for development and application has always been a research focus in pharmaceutics for its. Though literature survey of related papers published in domestic and foreign journals by Chinese authors in 2016, the research advances of materials of microspheres, which can be divided into natural polymer materials, synthetic polymer materials and inorganic materials, were summarized. Microsphere products at home and abroad were also analyzed. This review will provide some reference for correlative researchers.
  • [1]
    Zhao JJ,Shen LJ,Zhou JP.Research progress in materials for nano-carriers of targeted drug delivery system[J].Prog Pharm Sci(药学进展),2015,39(3):161-169.
    [2]
    Ni Q,Chen W,Lei T,et al.Preparation of novel biodegradable ropivacaine microspheres and evaluation of their efficacy in sciatic nerve block in mice[J].Drug Des Dev Ther,2016,10:2499-2506.
    [3]
    He M,Wang H,Dou W,et al.Preparation and drug release properties of norisoboldine-loaded chitosan microspheres[J].Int J Biol Macromol,2016,91:1101-1109.
    [4]
    Li J,Wang Q,Zhi W,et al.Immobilization of salvianolic acid B-loaded chitosan microspheres distributed three-dimensionally and homogeneously on the porous surface of hydroxyapatite scaffolds[J].Biomed Mater,2016,11(5):055014.
    [5]
    Li J,Yu X,Zhou G,et al.Synthesis and in vitro characterization of chitosan microspheres/ceramic bovine bone composite scaffold[J].J Peking Univ(Health Sci)(北京大学学报 医学版),2016,48(6):1043-1048.
    [6]
    Wu XL,Zhang C,Ping QN.Progress on modified chitosan applied in drug delivery system[J].Chin J Nat Med(中国天然药物),2009,7(6):458-464.
    [7]
    Liu SY,Bai XH,Dong LJ,et al.Formulation optimization and in vitro release of puerarin carboxymethylchitosan microspheres [J].Chin J Pharm(中国医药工业杂志),2016,47(3):299-304.
    [8]
    Gao YR,Yu NN,Li GY,Synthesis of chitosan-graft-β-cyclodextrin polymer hollow microsphere and its drug carrie property[J].Ion Exchange Adsorpt(离子交换与吸附),2016(5):414-422.
    [9]
    Feng Y,Kopplin G,Sato K,et al.Alginate gels with a combination of calcium and chitosan oligomer mixtures as crosslinkers[J].Carbohydr Polym,2016,156:490-497.
    [10]
    Shen LH,Deng YP,Wang XY,et al.A study on fluoxetine hydrochloride floating calcium alginate microspheres in vitro and in vivo[J].J Fujian Med Univ(福建医科大学学报),2016,50(2):82-87.
    [11]
    Wang QS,Wang GF,Zhou J,et al.Colon targeted oral drug deli-very system based on chitosan/alginate microspheres loaded with icariin in the treatment of ulcerative colitis[J].Int J Pharm,2016,515(1/2):176-185.
    [12]
    Mao YM, Zhao M, Ge Y, et al. Novel alginate-chitosan composite microspheres for implant delivery of vancomycin and in vivo evaluation[J].Chem Biol Drug Des,2016,88(3):434-440.
    [13]
    Qi X,Qin X,Yang R,et al.Intra-articular administration of chitosan thermosensitive in situ,hydrogels combined with diclofenac sodium-loaded alginate microspheres[J].J Pharm Sci,2016,105(1):122-130.
    [14]
    Zhang Y,Meng C,Chang J,et al.Preparation and characterization of a self-assembled tea polyphenol-gelatin-chitosan nanoparticles[J].J China Pharm Univ(中国药科大学学报),2014,45(2):178-184.
    [15]
    Chou SF,Luo LJ,Lai JY,et al.On the importance of bloom number of gelatin to the development of biodegradable in situ gelling copolymers for intracameral drug delivery[J].Int J Pharm,2016,511(1):30-43.
    [16]
    Yan J,Miao Y,Tan H,et al.Injectable alginate/hydroxyapatite gel scaffold combined with gelatin microspheres for drug delivery and bone tissue engineering[J].Mater Sci Eng C,2016,63:274-284.
    [17]
    Liu W,Chen J,Hu KJ,et al.Sustain-released gelatin microspheres loaded with CGRP/SP for repairing bone defect of osteoporosis rabbits [J].J Oral Sci Res(口腔医学研究),2016,32(3):228-233.
    [18]
    Sui XY,Zhang L,Liu C,et al.Preparation and quality evaluation of starch microspheres of diclofenac sodium[J].Chin Pharm J(中国药学杂志),2016,51(7):554-560.
    [19]
    Shi SL, Li XQ, Shi XH, et al. Preparation of gastrodin starch microsphere and its nasal mucoadhesion and in vitro release characteristics [J].Chin Tradit Herb Drugs(中草药),2016,47(4):585-590.
    [20]
    Si XF,Lv JX,Li Y,et al.Preparation and application of porous starch microspheres[J].J Dalian Polytech Univ(大连工业大学学报),2016(6):452-456.
    [21]
    Tang ZM,Ma XB.Chemical modification of poly(lactic acid)and its research progress[J].Modern Chem Ind(现代化工),2016(5):17-20.
    [22]
    Zhang L,Li Y,Zhang Y,et al.Sustained release of isoniazid from polylactide microspheres prepared using solid/oil drug loading method for tuberculosis treatment[J].Sci China,2016,59(7):1-8.
    [23]
    Wang Y,Zhu LH,Chen AZ,et al.One-step method to prepare PLLA porous microspheres in a high-voltage electrostatic anti-solvent process[J].Materials,2016,9(5):368.
    [24]
    Wei Y,Wang Y,Zhang H,et al.A novel strategy for the preparation of porous microspheres and its application in peptide drug loading[J].J Colloid Interface Sci,2016,478(9):46-53.
    [25]
    Lu Q,Che ZH,Chen NN,et al.Preparation of total flavonoids of chrysanthemum indicum(TFC)-PLGA sustained release microspheres and its optimization of technology[J].J Jilin Univ(Med Ed)(吉林大学学报 医学版),2016(3):617-621.
    [26]
    Liu Z,Xia L,Xiu B,et al.A novel and simple preparative method for uniform-sized PLGA microspheres:preliminary application in antitubercular drug delivery[J].Colloids Surf B Biointerfaces,2016,145:679-687.
    [27]
    Wu J,Williams GR,Branford-White C,et al.Liraglutide-loaded poly(lactic-co-glycolic acid)microspheres:preparation and in vivo evaluation[J].Eur J Pharm Sci,2016,92:28-38.
    [28]
    Wang P,Wang Q,Ren T,et al.Effects of pluronic F127-PEG multi-gel-core on the release profile and pharmacodynamics of Exenatide loaded in PLGA microspheres[J].Colloids Surf B Biointerfaces,2016,147:360-367.
    [29]
    Lyu YY.Preparation and property research of drug and gene carriers based on superparamagnetic nanoparticles[D].Changchun:Jilin University,2013.
    [30]
    Li L,Wu YQ,Sun KK,et al.Controllable preparation and drug loading properties of core-shell microspheres Fe3O4 @MOFs/GO[J].Mater Lett,2016,162:207-210.
    [31]
    Di HW, Cao JP, Wei JJ. The characterization and drug release behavior research of P(MAA-co-AAm)/Fe3O4 as polymer magnetic microsphere[J].J Jiangxi Normal Univ(Nat Sci)(江西师范大学学报 自然科学版),2016(1):93-97.
    [32]
    Lai W,Chen C,Ren X,et al.Hydrothermal fabrication of porous hollow hydroxyapatite microspheres for a drug delivery system[J].Mater Sci Eng,2016,62:166-172.
    [33]
    Xiao Q, Zhou K, Chen C, et al. Hollow and porous hydroxyapatite microspheres prepared with an O/W emulsion by spray freezing method[J].Mater Sci Eng,2016,69:1068-1074.
    [34]
    Li H, Jiang F, Ye S, et al. Bioactive apatite incorporated alginate microspheres with sustained drug-delivery for bone regeneration application[J].Mater Sci Eng,2016,62:779-786.
    [35]
    Zhong QW, Cai YR. Preparation of CaCO3 and hydroxyapatite microsphere and its potential application in drug-controlled release[J].J Zhejiang Sci-Tech Univ(Nat Sci)(浙江理工大学学报 自然科学版),2016,35(5):685-690.
    [36]
    Chen JW, Shen J, Hu WY, et al. Synthesis and mechanism research of calcium carbonate microspheres[J].China Powder Sci Technol(中国粉体技术),2016(6):69-74.
    [37]
    Zhou Z,Li Y,Yao S,et al.Preparation of calcium carbonate@graphene oxide core-shell microspheres in ethylene glycol for drug delivery[J].Ceramics Int,2016,42(2):2281-2288.
    [38]
    Li J,Jiang H,Ouyang X,et al.CaCO3/Tetraethylenepentamine-graphene hollow microspheres as biocompatible bone drug carriers for controlled release[J].ACS Appl Mater Interfaces,2016,8(44):30027.
    [39]
    Xu H,Li YA,Zhou HJ,et al.Preparation of chlorpyrifos/calcium carbonate composite microsphere and their sustained release property[J].New Chem Mater(化工新型材料),2016(12):137-139.
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