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MA Jingjie, CHEN Yimeng, JIANG Qixin, YANG Jie, WEN Xiaodong. Effects of ethanol extract of Si Miao Wan on hepatic lipid accumulation[J]. Journal of China Pharmaceutical University, 2021, 52(6): 725-734. DOI: 10.11665/j.issn.1000-5048.20210611
Citation: MA Jingjie, CHEN Yimeng, JIANG Qixin, YANG Jie, WEN Xiaodong. Effects of ethanol extract of Si Miao Wan on hepatic lipid accumulation[J]. Journal of China Pharmaceutical University, 2021, 52(6): 725-734. DOI: 10.11665/j.issn.1000-5048.20210611
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Effects of ethanol extract of Si Miao Wan on hepatic lipid accumulation

  • State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Key R&D Program of China （No.2018YFC1704500， No.2018YFC1704503）
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  • Received Date: May 16, 2021
  • Revised Date: October 28, 2021
    Graphical Abstract
    • Abstract
  • This study aimed to investigate the ameliorative effects of 60% ethanol elution fraction (ESMW) from Si Miao Wan on the hepatic lipid accumulation and its mechanism.TG kit, BODIPY fluorescence staining, QPCR, WB, oil red O staining, and AMPKα knockdown were used to detect the ability of ESMW to improve lipid accumulation in hepatocytes stimulated with free fatty acid.Furthermore, the effects of ESMW on the oral glucose tolerance, serum biochemical indexes, TG content in liver tissue, the expressions of mRNA and protein related to lipid metabolism in liver tissue were studied in mice fed with high fat diet to verify the mechanism of ESMW fraction on hepatic lipid accumulation.The results showed that ESMW inhibited lipid accumulation induced by free fatty acids by regulating AMPK signaling pathway, and that ESMW significantly improved the lipid metabolism of mice fed with high fat diet, with relation to AMPK signaling pathway.
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    • References (11)
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